(alendronate Sodium) Tablets and Oral Solution
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چکیده
FOSAMAX® (alendronate sodium) is a bisphosphonate that acts as a specific inhibitor of osteoclastmediated bone resorption. Bisphosphonates are synthetic analogs of pyrophosphate that bind to the hydroxyapatite found in bone. Alendronate sodium is chemically described as (4-amino-1-hydroxybutylidene) bisphosphonic acid monosodium salt trihydrate. The empirical formula of alendronate sodium is C4H12NNaO7P2•3H2O and its formula weight is 325.12. The structural formula is:
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Findings from endoscopic studies in patients with esophagitis caused by alendronate are associated with chemical esophagitis, similar to that caused by acetylsalicylic acid.7 The pathophysiological mechanism involved in these cases was direct irritation of the mucosa due to prolonged exposure to the drug. The same mechanism could apply to our patients who allowed tablets to dissolve in their mo...
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mg/d alendronate sodium with calcium salts for 1 year. The patient consulted 3 days after the presentation of extremely painful ulcers on the oral mucosa, palate, tongue, and lower lip. Following careful questioning, the patient reported having allowed the alendronate tablet to dissolve in his mouth on one occasion several days previously because he was traveling. The second case was a 57-year-...
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PURPOSE The aim of this study was to evaluate the bioequivalence of a generic product 70 mg alendronate sodium tablets with the reference product Fosamax® 70 mg tablet. MATERIALS AND METHODS A single-center, open-label, randomized, three-period, three-sequence, reference-replicated crossover study was performed in 36 healthy Chinese male volunteers under fasting conditions. In each study peri...
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OBJECTIVE To evaluate the efficacy and safety of oral alendronate sodium therapy once daily in preventing glucocorticoid-induced bone loss in patients with immunobullous skin diseases treated with long-term glucocorticoid therapy. DESIGN A 12-month randomized, double-blind, placebo-controlled trial. SETTING A tertiary referral dermatology center in Singapore. PARTICIPANTS Patients newly d...
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In this study, alendronate, the most commonly used biphosphonate for treating osteoporosis, was formulated as gastroretentive dosage form (GRDF) tablets to enhance its oral bioavailability. GRDF tablets were characterized with the effects of different molecular weights (MWs) of chitosan (CS) and hydroxyethyl cellulose (HEC) at various ratios on swelling, floating, and physical integrity. The CS...
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